the pet digest blog from Nusentia

Enzymes: Benefits Beyond Digestion

Digestive enzymes bring benefits beyond simple digestion. Of course, enzymes are vital for pets with enzyme deficiency and for senior pets as well. But, you may be surprised to know that new scientific indicators show that enzymes have systemic benefits as well. Hence, digestive enzymes may enhance many other systems in the body to improve pet health.*

Related: The Difference Between Systemic Enzymes & Digestive Enzymes

Some digestive enzymes reach beyond the stomach, and science is now studying their systemic mechanisms. Systemic enzymes tend to be positioned for condition-specific use: anti-inflammatory issues, joint health, and cardiovascular health. 

Did you know? Dietary enzymes can address systemic issues, such as inflammation, joint health, and even cardiovascular issues.

Systemic enzymes are predominantly protease enzymes (protein catalysts). There are multiple proteases, including protease 6.0, bromelain, peptidase, protease 4.5, and protease 3.0. These protease enzymes act as both digestive and systemic enzymes by nature and are found in Nusentia®'s Enzyme Miracle® for dogs and cats.

Proteases and the Immune System

In the immune system, protease enzymes are prized for their ability to break down proteins. For the reason that many potential pathogens, such as bacteria and the outer shell of viruses, are protein-based. Proteases can break down such protein invaders to the body, but they can also help activate immune cells. Using protease enzymes are great for pets with sensitive immune systems or allergies.

Broad-Spectrum Enzymes are Best

Our approach at Nusentia® provides an enzyme formula that is spot on in addressing digestive burden. Our vegetarian enzyme blend for dogs and cats maximizes nutrition through complete digestion but also systemic support. And, unlike pancreatic enzymes (animal-based enzymes), Enzyme Miracle® goes to work right away without presoaking requirements or waiting.

Likewise, enzymes and probiotics are great companions, which is why we offer the Miracle PackEnzyme Miracle® is packed with a variety of proteases and other supporting enzymes to help pets thrive.

These broad spectrum formulas provide optimal health for your pets without the negative side effects associated with animal-based enzymes.

Learn more about animal-based enzymes in our article: The Difference Between Systemic Enzymes & Digestive Enzymes


Engwerda CR et al. “Bromelain modulates T cell and B cell immune responses in vitro and in vivo.” Cell Immunol. 2001 May 25;210(1):66-75.

Barth H et al. “In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.” Eur J Med Res. 2005 Aug 17;10(8):325-31.

Metzig C et al. “Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo.” In Vivo. 1999 Jan-Feb;13(1):7-12.

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