the pet digest blog from Nusentia

MSM: Secret Agent for Joint Health

Methylsulfonylmethane (MSM) is a unique ingredient that offers great benefits for the joints even when already in the arthritic state. All of the biochemical properties of MSM are not fully understood, but, it has some interesting benefits for canine and horse joint health. Regardless of its benefits though, MSM is curiously absent in many joint supplements.

MSM is a sulfur containing natural compound found in many green plants. While there are multiple studies regarding MSM, its most convincing evidence is with use for arthritis. MSM acts as an anti inflammatory and as a hydrating, waste-removal machine in the body. It is the perfect compliment to Glucosamine and Chondroitin, which feed the joint tissues (glycosaminoglycans). 

horse joint xray

3 Benefits of MSM

1. Improves Flexibility

Research has shown that MSM is highly effective in improving joint flexibility via the restoration of the hydration of tissue. This is important for horses and dogs to remain active and mobile.

2. Normalizes Inflammation Response

MSM has powerful anti-inflammatory properties due to its ability to allow metabolic wastes to be removed from the cells. In short, animals with inflammation pain may experience less pain when provided MSM to the diet.

3. Detoxifies the Body

One of the most important features of MSM is that it makes the cells more permeable. MSM serves to move toxins and metabolic waste products out of the cells, while essential nutrients and hydration can be moved in.

We believe MSM should be included in all joint formulas and serves to be part of the "Big 3" natural nutrients for joint health. Together with glucosamine sulfate and chondroitin sulfate, Nusentia®’s RJX formulations contain significant, therapeutic dosages of MSM. This liquid formula has help countless dogs and horses back to mobility.


Pearson TW, Dawson HJ, Lackey HB. Natural occurring levels of dimethyl sulfoxide in selected fruits, vegetables, grains, and beverages. J Agric Food Chem 1981;29:1089-1091.

Marañón G, Muñoz-Escassi B, Manley W, et al. The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise. Acta Vet Scand . 2008;50:45.

Beilke MA, Collins-Lech C, Sohnle PG. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. J Lab Clin Med 1987;110:91-96.

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