German Shepherd Dog Exocrine Pancreatic InsufficiencyIs your dog losing weight and having stomach problems? Your dog may be suffering from Exocrine Pancreatic Insufficiency (EPI).  EPI is more common than you may think, and dogs with EPI can have their owners feeling like their pet is helplessly fading away right before their eyes. There has been an increased awareness especially in the last 10 years about EPI, and, while the condition can be mostly attributed to genetics, there is hope for dog owners who desire to give their dogs a longer, healthier, even normal life through natural care and nutrition. 

Exocrine pancreatic insufficiency (EPI)

EPI is the inability to properly digest food due to a lack of digestive enzymes made by the pancreas. Loss of digestive enzymes leads to maldigestion and malabsorption of nutrients. This is not the same as pancreatitis, which is basically inflammation of the pancreas. Rather, EPI is caused by a progressive loss of the pancreatic cells that make digestive enzymes. Dogs and cats can both suffer from EPI, though they usually have different pathologies, and EPI is much less common in cats. In dogs, EPI is most commonly caused by pancreatic acinar atrophy. In cats, the primary cause is chronic pancreatitis. Beyond genetics, which researchers believe plays a large role, the root cause can also traced to poor diet or health, which ultimately causes a burden on pancreatic function.

Which breeds are most at risk for EPI?

In dogs, EPI is most common in young German Shepherd Dogs (GSD), which make up about one-half to two-thirds of all cases. Other breeds that seem to be predisposed to EPI include terrier breeds, Cavalier King Charles Spaniels, Chihuahuas, Chow Chows, and Picardien Shepherd.

Symptoms of Exocrine Pancreatic Insufficiency

  • Weight loss
  • Poor coat quality
  • Gas
  • Increased appetite
  • Diarrhea
  • Change in feces (to yellow-gray color and oily)

The one, two punch to knock out EPI through nutrition

1: Enzyme Supplementation

The Miracle Pack

The Miracle Pack offers the "one, two punch" needed to nutritionally knock out EPI. Both digestive enzymes and probiotics will lead your pet back to health. (Click image to learn more )

Most dogs and cats with EPI can be successfully treated by dietary supplementation with pancreatic enzymes. Most experts on the subject will tell you that powdered enzymes are more effective than tablets, capsules, and especially enteric-coated products.

Nusentia’s Enzyme Miracle™ comes in powder form and delivers all the enzymes that dogs and cats need for digestion.

In about 10% of dogs that have EPI, enzyme supplementation can cause some oral bleeding. If this happens, you (a) can moisten the food and powder, or (b) lower the dose. This will stop the problem.

2: Probiotics

One of the other problems in pets with EPI is that their gut health can suffer. In dogs with EPI, they often have concurrent small intestinal bacterial overgrowth (SBO), while cats with Exocrine Pancreatic Insufficiency often have concurrent inflammatory bowel disease (IBD). Conventional treatment would be to have antibiotics, but in fact both of these areas can be addressed naturally and effectively by using therapeutic probiotics. These “healthy” bacteria serve to counteract SBO by being competitive and overrunning the bad bacteria, which ultimately leads to their die-off. In IBD, there are specific species of probiotics that have anti-inflammatory effects.

Nusentia’s Probiotic Miracle™ is specifically designed for pets, and contains a scientific blend of six strains which have been demonstrated to restore proper gut function.

These actions restore balance to the gut in favor of health. While every dog is different, the results may vary, and make sure you consult with your vet. And while you’re at it, talk to your vet about adding B12 and a low-fiber diet. These nutritional interventions can address EPI effectively and help lead your pet back to health.

Customer Testimonial (excerpt from Amazon)

I have a Lhasa Apso that is 10 years old and was recently diagnosed with diabetes. I was instructed by her veterinarian that I would have to change her diet completely… As I struggled to get her blood sugar under control with insulin her weight began to drop slowly over time as she became more and more finicky with her new diet. Not only was her weight dropping and she constantly going through bouts of diarrhea but her overall appearance was getting worse, her coat was dry and rough to the touch. I started researching her symptoms online and came across what I believe she may have been suffering from for a long time even before the diabetes. I believe she has EPI (Exocrine Pancreatic Insufficiency)… It was at this time I purchased Nusentia’s Enzyme Miracle for dogs and what a difference it has made for my dog. Almost immediately she started eating better which allowed me to better control her blood sugar with insulin. Within a couple weeks she had started to gain some of her weight back and her coat is nice and soft again just like when she was a younger dog. As for the bouts of diarrhea she has not had any for several months now and I no longer have to give her the oral medications that the veterinarian would prescribe for the bouts of diarrhea. This product has truly been a miracle product for my dog and I. I would highly recommend this product to anyone who wants to help their dog be as healthy as possible throughout their life.


Westermarck E, Wiberg M (2003). “Exocrine pancreatic insufficiency in dogs”. Vet Clin North Am Small Anim Pract 33 (5): 1165–79, viii–ix. doi:10.1016/S0195-5616(03)00057-3. PMID 14552166.

Clark L, Wahl J, Steiner J, Zhou W, Ji W, Famula T, Williams D, Murphy K (2005). “Linkage analysis and gene expression profile of pancreatic acinar atrophy in the German Shepherd Dog”. Mamm Genome 16 (12): 955–62. doi:10.1007/s00335-005-0076-1. PMID 16341675.

Wiberg M, Saari S, Westermarck E (1999). “Exocrine pancreatic atrophy in German Shepherd Dogs and Rough-coated Collies: an end result of lymphocytic pancreatitis”. Vet Pathol 36 (6): 530–41. doi:10.1354/vp.36-6-530. PMID 10568434.

Rallis, Timoleon S.; Adamama-Moraitou, K. (2004). “Exocrine Pancreatic Insufficiency in Dogs and Cats: An Update”. Proceedings of the 29th World Congress of the World Small Animal Veterinary Association. Retrieved 2007-02-24.

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† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using this product.

* Disclaimer: The entire contents of this website are based upon the opinions of Nusentia, unless otherwise noted. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Nusentia's experts and the Nusentia community. We encourage you to make your own health care decisions for your pet based upon your research and in partnership with a qualified veterinarian or health care professional.